Security implications of VM Persistence

How risky is it from a security perspective, not a privacy perspective, to create a persistent Whonix workstation VM for the sole purpose of retrieving and storing client-side emails on Thunderbird?

I will enable the opening of links and attachments through a separate disposable VM, I will also enable the clipboard to cross over VMs, aside from this there will be no other functionality installed into this persistent Whonix VM other than retrieving and storing emails within the Thunderbird email client application.

What level of security risk may persistence pose to such a Whonix VM?

Whonix security (unrelated to any privacy or anonymity considerations) doesn’t get worsened by using persistence.

This is unspecific to Whonix. Could rephrase the same question with Debian.

How risky is it from a security perspective, not a privacy perspective, to create a persistent Debian VM for the sole purpose of retrieving and storing client-side emails on Thunderbird?