Sculpt-Whonix (Qubes-Whonix without the Qubes)

Since Qubes and Genode both utilize a network of sandboxed virtual containers each running its own operating system, I’m toying with the idea of replacing Qubes OS with Sculpt OS (Genode’s flagship) as the host for the Whonix gateway and workstation. Has anyone tried this before? Is there a reason why it shouldn’t be done?