This is the same problem reported in https://www.whonix.org/forum/index.php/topic,1129.0.html. It has to do with version of the AppArmor profile you are using.
If you want to update Tor Browser with its own updater, you should install the latest profile because TBB 4.5ax creates new updating directories.
(i was just talking about mknod , well here we go => mkdir)
For information, the relevant part in the message is "Name:" which gives the name of the denied file.
The recommended practice for reporting AppArmor message is the following:
In a terminal, run
sudo tail -f /var/log/kern.log
All the denied messages will be shown as they happen. Paste them between code tags (code /code inside square brackets).
Apr 12 21:25:13 host kernel: [ 4881.006470] type=1400 audit(1428873913.681:74): apparmor="DENIED" operation="open" parent=21362 profile="/usr/bin/whonixcheck" name="/usr/bin/tty" pid=21506 comm="whonixcheck" requested_mask="r" denied_mask="r" fsuid=1000 ouid=0