Hardware wallets are unfortunately very difficult to use in combination with Qubes.
If Trezor can be made with Qubes Debian based App Qubes, then it should also be functional with Qubes-Whonix-Workstation based Qubes. But that’s a big “if”.
But I would guess, probably:
Hardware wallets may be unnecessary in many threat models. Especially when using online/offline split-VMs instead, which is simple with Qubes.