Connection Safe or not?

Can I use this setup
VPN → Whonix → Remmina RDP client → RDP/VPS

Would this be safe? Or what could possibly go wrong, any tips appreciated. And I’m running this on Qubes OS.

So to summarize the main goal is to have a usable connection (not ping5000) and also as anonymous as possible. I fear only using vpn to connect to server would not be enough.