twuewand - a truerand algorithm for generating entropy - Whonix integration

rdrand is unrelated. distrusting RDRAND is a separate.

There is probably no need to configure per application. The Linux kernel provides APIs, entropy pools. You could learn more about that here: good read on the linux security wrt to entropy / randomness

By installing and configuring twuewand, the entropy quality might get better. All applications would benefit from that without further action required.

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