Yes. I use security-misc on ParrotOS which is a Debian based distribution and it runs with no problems. The experimental options might introduce some minor issues like not being able to re-log in after logging out. security-misc can be installed as explained here security-misc: Enhance Miscellaneous Security Settings. LKRG can be installed in Ubuntu as explained here Linux Kernel Runtime Guard (LKRG) for Debian, Whonix, Qubes, Kicksecure ™. Be aware that in my ParrotOS that uses the latest Stable Linux Kernel LKRG won’t run. I haven’t looked into it so I don’t know why. Also having LKRG installed on your host OS and trying to run Whonix or other VMs in Virtualbox may lead to this bug lkrg-users - bug: LKRG kills VirtualBox host VMs. It will run in VMs though. If you mean Whonix as host OS not atm. Look here Whonix-Host Operating System Live ISO, Whonix-Host Installer and Whonix host operating system
Also check this to see what packages are safe to be installed on Debian hosts Whonix ™ Packages for Debian Hosts and Whonix ™ Host Enhancements
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